Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
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DOI：
10.1038/382133a0
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发表时间：
1996-07-11
期刊：
影响因子：
64.8
通讯作者：
Carroll, SB
中科院分区：
文献类型：
--
作者：
Kim, J;Sebring, A;Carroll, SB
细胞的形成是由来自离散来源的信号组织的，这些信号可能作用于下游基因以控制生长和模式。果蝇的退化基因是翅细胞增殖的选择性必需基因，足以诱导眼睛、腿和触角的翅组织生长出来。不同的信号激活单独的增强子来控制残留表达：首先，在背侧/腹侧组织者通过Notch途径，随后，在发育中的翼片通过decapentaplegic和来自背侧/腹侧组织者的信号。信号整合一定是像退化基因这样的基因的一个普遍特征，它沿着不止一个轴调节生长或模式。
Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.