Pharmacogenetics and pharmacogenomics of anticancer agents.
Pharmacogenetics and pharmacogenomics of anticancer agents.
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DOI：
10.3322/caac.20002
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Ratain MJ
中科院分区：
文献类型：
--
作者：
Huang RS;Ratain MJ
在与抗癌治疗相关的反应和毒性方面，观察到很大的个体间差异。这种变异的病因是多因素的，但部分原因是宿主遗传变异。药物遗传学和药物基因组学研究已经成功地确定了导致这种化疗易感性变化的遗传变异。本文概述了药物遗传学和药物基因组学领域的进展，采用五阶段架构，其中包括：1)确定遗传学在药物反应中的作用；2)筛选和鉴定遗传标记；3)遗传标记验证；4)临床效用评估；5)药物经济学影响。举例说明了这些药物遗传学和药物基因组学标记的识别、验证、效用和挑战，重点是这些知识在癌症治疗中的当前应用。随着技术的进步，以一种相对廉价和高效的方式评估人类基因组已成为可能；然而，迫切需要广泛的药物遗传学研究和教育，以提高药物遗传学概念从实验室到床边的转化。
Large interindividual variation is observed in both the response and toxicity associated with anticancer therapy. The etiology of this variation is multifactorial, but is due in part to host genetic variations. Pharmacogenetic and pharmacogenomic studies have successfully identified genetic variants that contribute to this variation in susceptibility to chemotherapy. This review provides an overview of the progress made in the field of pharmacogenetics and pharmacogenomics using a five-stage architecture, which includes 1) determining the role of genetics in drug response; 2) screening and identifying genetic markers; 3) validating genetic markers; 4) clinical utility assessment; and 5) pharmacoeconomic impact. Examples are provided to illustrate the identification, validation, utility, and challenges of these pharmacogenetic and pharmacogenomic markers, with the focus on the current application of this knowledge in cancer therapy. With the advance of technology, it becomes feasible to evaluate the human genome in a relatively inexpensive and efficient manner; however, extensive pharmacogenetic research and education are urgently needed to improve the translation of pharmacogenetic concepts from bench to bedside.
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影响因子：
2.1
作者：
Etienne-Grimaldi, Marie-Christine;Francoual, Mireille;Milano, Gerard
通讯作者：
Milano, Gerard
影响因子：
6.7
作者：
de Jong, F. A.;Scott-Horton, T. J.;Sparreboom, A.
通讯作者：
Sparreboom, A.
影响因子：
2.8
作者：
Baudhuin, Linnea M.;Highsmith, W. Edward;O'Kane, Dennis J.
通讯作者：
O'Kane, Dennis J.
影响因子：
11.2
作者：
Dolan, ME;Newbold, KG;Badner, JA
通讯作者：
Badner, JA
影响因子：
158.5
作者：
BOSMA, PJ;CHOWDHURY, JR;CHOWDHURY, NR
通讯作者：
CHOWDHURY, NR