Synthesis and biological activities of 2-functionalized purine nucleosides.
Synthesis and biological activities of 2-functionalized purine nucleosides.
复制标题
2-功能化嘌呤核苷的合成和生物活性。
DOI：
10.1081/ncn-120019498
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kern,EarlR
中科院分区：
文献类型：
--
作者：
Nair,Vasu;Bera,Bindu;Kern,EarlR
Novel purine nucleosides functionalized at the 2-position have been prepared using new applications of synthetic methodology. The target molecules were designed as potential inhibitors (as their monophosphates) of the enzyme, inosine monophosphate dehydrogenase (IMPDH), and representative inhibition data are presented. Antiviral data of the compounds are discussed.
