Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis.
Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis.
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人肝细胞癌的染色体改变与探索性CGH荟萃分析的病因学和组织学等级相关。
DOI：
10.1038/sj.bjc.6602448
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发表时间：
2005-03-14
影响因子：
8.8
通讯作者：
Schirmacher, P
中科院分区：
文献类型：
--
作者：
Moinzadeh, P;Breuhahn, K;Stützer, H;Schirmacher, P
关键词：
对人类肝细胞癌 (HCC；n=785) 和癌前发育异常结节 (DN；n=30) 的所有可用比较基因组杂交 (CGH) 分析（n=31，直至 12/2003）进行了汇编，并与临床和组织学参数相关。基因组材料最显着的扩增存在于 1q (57.1%)、8q (46.6%)、6p (22.3%) 和 17q (22.2%) 中，而损失最常见于 8p (38%)、16q (35.9%)、4q (34.3%)、17p (32.1%) 和 13q （26.2%）。 4q、16q、13q和8p缺失与乙型肝炎病毒病因呈正相关，而8p缺失更常见于丙型肝炎病毒阴性病例。在低分化 HCC 中，13q 和 4q 的代表性明显不足。此外，1q 的增益与 HCC 中所有其他高频改变的发生呈正相关。在 DN 中，扩增最常见于 1q 和 8q，而缺失发生于 8p、17p、5p、13q、14q 和 16q。总之，病因学和去分化与人类 HCC 的特定基因组改变相关。 1q 的增加似乎是相当早期的事件，可能会导致进一步的染色体异常。因此，探索性 CGH 荟萃分析产生了关于人类 HCC 基因组改变的原因和功能意义的新颖且可测试的假设。
All available comparative genomic hybridisation (CGH) analyses (n=31, until 12/2003) of human hepatocellular carcinomas (HCCs; n=785) and premalignant dysplastic nodules (DNs; n=30) were compiled and correlated with clinical and histological parameters. The most prominent amplifications of genomic material were present in 1q (57.1%), 8q (46.6%), 6p (22.3%), and 17q (22.2%), while losses were most prevalent in 8p (38%), 16q (35.9%), 4q (34.3%), 17p (32.1%), and 13q (26.2%). Deletions of 4q, 16q, 13q, and 8p positively correlated with hepatitis B virus aetiology, while losses of 8p were more frequently found in hepatitis C virus-negative cases. In poorly differentiated HCCs, 13q and 4q were significantly under-represented. Moreover, gains of 1q were positively correlated with the occurrence of all other high-frequency alterations in HCCs. In DNs, amplifications were most frequently present in 1q and 8q, while deletions occurred in 8p, 17p, 5p, 13q, 14q, and 16q. In conclusion, aetiology and dedifferentiation correlate with specific genomic alterations in human HCCs. Gains of 1q appear to be rather early events that may predispose to further chromosomal abnormalities. Thus, explorative CGH meta-analysis generates novel and testable hypotheses regarding the cause and functional significance of genomic alterations in human HCCs.
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影响因子：
10.5
作者：
NAGAYA, T;NAKAMURA, T;MATSUBARA, K
通讯作者：
MATSUBARA, K
DOI：
10.1046/j.1440-1746.2003.02973.x
发表时间：
2003-03-01
影响因子：
4.1
作者：
Cui, J;Zhou, XD;Romeih, M
通讯作者：
Romeih, M
影响因子：
2.9
作者：
El-Serag, HB
通讯作者：
El-Serag, HB
影响因子：
13.5
作者：
Kern, MA;Schubert, D;Schirmacher, P
通讯作者：
Schirmacher, P
影响因子：
7.3
作者：
Prange, W;Breuhahn, K;Schirmacher, P
通讯作者：
Schirmacher, P