Low-density lipoprotein cholesterol estimation by a new formula in Indian population
Low-density lipoprotein cholesterol estimation by a new formula in Indian population
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DOI：
10.1016/j.ijcard.2004.05.009
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发表时间：
2005-06-22
影响因子：
3.5
通讯作者：
Talwar, KK
中科院分区：
文献类型：
--
作者：
Anandaraja, S;Narang, R;Talwar, KK
背景：低密度脂蛋白胆固醇的测定对于缺血性心脏病患者的治疗至关重要。出于逻辑原因，世界各地的实验室通常通过应用弗里德瓦尔德公式来计算低密度脂蛋白胆固醇。我们基于多元回归方法得出了一个新公式。方法：对 2008 名患者的血液样本进行血脂分析。在最初的 1000 名患者中，通过直接法和 Friedewald 公式估算了低密度脂蛋白胆固醇。通过对直接估计法的数据应用线性回归方法，得到一个新公式，并在接下来的 1008 名患者中验证了该新公式的准确性。结果：通过直接低密度脂蛋白胆固醇测定法测量的平均低密度脂蛋白胆固醇为 116 +/- 41.5 mg/dl (3.02 +/- 1.08 mmol/l)，通过 Friedewald 公式计算得出的平均低密度脂蛋白胆固醇为 119 +/- 46 mg/dl最初的 1000 名患者为 (3.09 +/- 1.2 mmol/l)。通过直接低密度脂蛋白胆固醇测定法测量的低密度脂蛋白胆固醇和根据 Friedewald 公式计算的低密度脂蛋白胆固醇显示出良好的相关性 (r = 0.88)，但是 Friedewald 公式的高估程度很小。排除甘油三酯超过 350 mg/dl 的患者后，直接低密度脂蛋白胆固醇与计算低密度脂蛋白胆固醇之间的相关性得到改善 (r = 0.92)。通过直接测定和新配方在接下来的 1008 名患者中测量的平均低密度脂蛋白胆固醇分别为 117 +/- 40 mg/dl (3.04 +/- 1.04 mmol/l) 和 113.7 +/- 37 mg/dl (2.96 +/- 0.96 mmol/l)，它们之间具有非常好的相关性 (r=0.97)。 结论：新配方源自在印度人口中，多元线性回归分析似乎比弗里德瓦尔德公式更准确。 (c) 2004 Elsevier Ireland Ltd. 保留所有权利。
Background: Estimation of low-density lipoprotein cholesterol is crucial in the management of ischemic heart disease patients. Low-density lipoprotein cholesterol is routinely calculated in laboratories world over by applying Friedewald formula for logistic reasons. We derived a new formula based on multiple regression approach.Methods: Lipid profiles were done on blood samples of 2008 patients. In initial 1000 patients, low-density lipoprotein cholesterol was estimated by a direct method and also by Friedewald formula. By applying linear regression methods on the data of direct estimation method, a new formula was obtained and the accuracy of this new formula was validated in the next 1008 patients.Results: The mean low-density lipoprotein cholesterol was 116 +/- 41.5 mg/dl (3.02 +/- 1.08 mmol/l) measured by direct low-density lipoprotein cholesterol assay and that calculated by Friedewald formula was 119 +/- 46 mg/dl (3.09 +/- 1.2 mmol/l) for the initial 1000 patients. Low-density lipoprotein cholesterol measured by direct low-density lipoprotein cholesterol assay and calculated from Friedewald formula showed good correlation (r = 0.88), however, there was minimal overestimation by the Friedewald formula. The correlation improved between direct low-density lipoprotein cholesterol and calculated low-density lipoprotein cholesterol after excluding the patients with triglycerides more than 350 mg/dl (r = 0.92). The mean low-density lipoprotein cholesterol measured by the direct assay and by new formula in the next 1008 patients was 117 +/- 40 mg/dl (3.04 +/- 1.04 mmol/l) and 113.7 +/- 37 mg/dl (2.96 +/- 0.96 mmol/l), respectively with very good correlation (r=0.97) between them.Conclusions: The new formula derived from multiple linear regression analysis appears to be more accurate than Friedewald formula in Indian population. (c) 2004 Elsevier Ireland Ltd. All rights reserved.