A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis
A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis
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DOI：
10.1007/s00535-006-1981-0
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发表时间：
2007-02-01
影响因子：
6.3
通讯作者：
Nagahori, Kaoru
中科院分区：
文献类型：
--
作者：
Kojima, Yasuyuki;Mogaki, Masatoshi;Nagahori, Kaoru
一名患有溃疡性结肠炎（UC）的25岁日本男性因早期结肠癌接受了两次内镜粘膜切除术，其随访结肠镜检查显示乙状结肠中存在一个新的直径为1.5 cm的肿瘤。术前活检诊断为低分化腺癌。行乙状结肠切除术，病理结果显示淋巴上皮瘤样癌（LEC）。原位杂交检测EB病毒（EBV）编码的小RNA在间质淋巴细胞中显示阳性信号，而在肿瘤细胞中显示弱信号。在这种情况下，EB病毒和LEC之间的联系是模糊的。与典型的UC介导的结肠癌不同，病变分化差，p53信号阴性。这些发现可能暗示了UC介导的结直肠癌的一种新的致癌机制。
Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.