Estradiol decreases the orexigenic effect of melanin-concentrating honnone in ovariectomized rats
Estradiol decreases the orexigenic effect of melanin-concentrating honnone in ovariectomized rats
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DOI：
10.1016/j.physbeh.2006.05.002
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发表时间：
2006-07-30
影响因子：
2.9
通讯作者：
Eckel, Lisa A.
中科院分区：
文献类型：
--
作者：
Messina, Michelina M.;Boersma, Gretha;Eckel, Lisa A.
雌二醇通过与厌氧肽的相互作用来抑制食物的摄取，如缩胆囊素，这些肽的作用是减少食物的摄入量。目前尚不清楚雌二醇是否也与促食欲素化合物相互作用，这些化合物与生理上控制食物摄入量有关。因此，这项研究的主要目标是确定雌二醇是否会降低黑色素浓缩激素(MCH)的食欲效应，MCH是一种神经肽，与雌二醇一样，似乎通过选择性地影响膳食大小的控制来影响食物的摄入量。侧脑室注射5mgMCH或生理盐水后，监测去卵巢大鼠的食物和水摄入量。在油处理的大鼠黑暗阶段的前4小时内，MCH增加了摄食量，但在雌激素处理的大鼠中，仅在相同的4小时间隔的最后2小时增加了摄食量。因此，与油类处理的大鼠相比，雌二醇处理的大鼠的促食欲作用显著降低。在MCH刺激喂养的这段时间内，没有观察到油或雌二醇组大鼠每餐水摄入量的增加。结论：雌二醇可降低去卵巢大鼠MCH的促食欲作用。(C)2006 Elsevier Inc.保留所有权利。
Estradiol exerts an inhibitory effect on food intake via interactions with anorexigenic peptides, like cholecystokinin, that function to decrease meal size. It is currently unknown whether estradiol also interacts with orexigenic compounds implicated in the physiological control of food intake. Thus, the primary goal of this study was to determine whether estradiol decreases the orexigenic effect of melanin-concentrating hormone (MCH), a neuropeptide that, like estradiol, appears to influence food intake by selectively affecting the controls of meal size. Food and water intake were monitored following lateral ventricular (icv) infusions of 5 mu g MCH or saline vehicle in oil- and estradiol-treated ovariectomized rats. MCH increased food intake throughout the first 4 h of the dark phase in oil-treated rats, but only for the last 2 It of the same 4-h interval in estradiol-treated rats. As a result, the orexigenic effect of MCH was significantly lower in estradiol-treated rats, relative to oil-treated rats. During this interval of MCH-stimulated feeding, a prandial increase in water intake was not observed in either oil- or estradiol-treated rats. We conclude that estradiol decreases the orexigenic effect of MCH in ovariectomized rats. (c) 2006 Elsevier Inc. All rights reserved.