Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome?
Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome?
复制标题
我们是否应该在抗磷脂综合征的筛查中包括抗凝血酶原抗体？
DOI：
10.1006/jaut.2000.0413
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发表时间：
2000
影响因子：
12.8
通讯作者：
M. Galli
中科院分区：
文献类型：
--
作者：
M. Galli
抗凝血酶原抗体属于抗磷脂抗体家族。它们的患病率在抗磷脂阳性患者中从50%到90%不等，这取决于检测他们所采用的实验室方法。酶联免疫吸附试验技术是最常用的测量方法，可以快速确定其效价和同种异型(S)。不幸的是，目前还没有商业化的标准化检测方法。抗凝血酶原抗体作为血栓栓塞症危险因素的临床相关性已经通过一些回顾性和病例对照研究进行了调查。我们回顾了11项研究：有1440名患者和371名性别和年龄匹配的对照组的数据可用。通过单变量分析，7项研究报告了抗凝血酶原抗体与血栓形成之间的显著关联。在五项研究中进行了多变量分析：只有两项研究证实了这种联系。根据抗体亚型和血栓形成的动脉和/或静脉部位分析抗凝血酶原抗体对血栓形成的敏感性和特异性。敏感性低得令人失望，特别是当考虑到M型和动脉血栓形成时，尽管范围很广，但特异性略好一些。这些数据不允许建议在抗磷脂阳性患者的常规实验室检查中测量抗凝血酶原抗体，以确定他们的血栓形成风险。
Anti-prothrombin antibodies belong to the family of the antiphospholipid antibodies. Their prevalence ranges from 50 to 90% of antiphospholipid-positive patients, depending on the laboratory methodology employed for their detection. ELISA techniques are the most commonly used methods for their measurements, which allow a quick determination of their titer and isotype(s). Unfortunately, no well standardized assays are yet commercially available. The clinical relevance of anti-prothrombin antibodies as risk factors for thromboembolic events has been investigated by a number of retrospective and case-control studies. We reviewed 11 studies: data on 1,440 patients and 371 sex- and age-matched controls were available. Seven studies reported a significant association between anti-prothrombin antibodies and thrombosis by univariate analysis. Multivariate analysis was performed in five studies: only two of them confirmed the association. The sensitivity and specificity of anti-prothrombin antibodies for thrombosis were analysed according to the antibody isotype and to the arterial and/or venous site of thrombosis. The sensitivities are disappointingly low, particularly when the M isotype and arterial thrombosis are considered, whereas the specificities are somewhat better, even though they range widely. These data do not allow to recommend the measurement of anti-prothrombin antibodies in the routine laboratory workout of antiphospholipid-positive patients in order to define their thrombotic risk.
影响因子：
20.3
作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao
通讯作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao