Clinical Significance of C-Reactive Protein-to-Albumin Ratio with Rectal Cancer Patient Undergoing Chemoradiotherapy Followed by Surgery
Clinical Significance of C-Reactive Protein-to-Albumin Ratio with Rectal Cancer Patient Undergoing Chemoradiotherapy Followed by Surgery
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DOI：
10.21873/anticanres.12022
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发表时间：
2017-10-01
影响因子：
2
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Ide, Shozo;Toiyama, Yuji;Kusunoki, Masato
背景/目的：本研究旨在评价C反应蛋白/白蛋白比值(CAR)在直肠癌患者术前放化疗(CRT)后的临床意义。患者和方法：这项回顾研究评估了115例局部进展期直肠癌患者CAR与预后的相关性。我们还进行了亚组分析，仅限于改良格拉斯哥预后评分(MGPS)低(0分)或病理TNM I-II期[ypN(-)]的患者。结果：CAR与性别、肿瘤侵袭、复发、血清癌胚抗原、MGPS有显著关系。CAR升高是所有患者总生存期(OS)和无病生存期(DFS)的独立预后因素。CAR升高也预示着病理TNM分期I-II[ypN(-)]和MGPS评分低的患者的OS和DFS较差。结论：CAR是预测CRT治疗直肠癌患者生存和复发的有前景的指标。
Background/Aim: This study was designed to evaluate the clinical significance of the C-reactive protein-to-albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery. Patients and Methods: This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)]. Results: CAR exhibited significant relationships with sex, tumor invasion, recurrence, serum carcinoembryonic antigen, and mGPS. Elevated CAR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) among all patients. Elevated CAR also predicted poor OS and DFS in patients with pathological TNM stage I-II [ypN(-)] and low mGPS score. Conclusion: CAR is a promising predictor of survival and recurrence in patients with rectal cancer treated by CRT.