Auditory P3 findings in Mission Indian youth
Auditory P3 findings in Mission Indian youth
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DOI：
10.15288/jsa.2001.62.562
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发表时间：
2001-09-01
期刊：
影响因子：
--
通讯作者：
Phillips, E
中科院分区：
文献类型：
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作者：
Ehlers, CL;Wall, TL;Phillips, E
目的：美洲原住民的酒精滥用和依赖率最高，但与许多部落中出现的饮酒问题相关的潜在生物风险因素仍然相对未知。在这项研究中，事件相关电位（ERP）的P3分量的振幅，与欧洲裔美国青年酗酒的风险相关的措施，在使命印度人进行了调查。方法：研究参与者为7至13岁的使命印度儿童和青少年（N = 68，37名男性）。事件相关电位收集使用两个听觉“oddball”范式：一个容易和一个困难的歧视任务。P3波幅和潜伏期作为年龄、性别、美洲原住民遗传程度（NAH）和酒精依赖家族史（FH）的函数进行统计学评估。结果如下：P3潜伏期随年龄和性别的变化而变化，女孩的潜伏期随年龄的增长比男孩减少得更多，这表明成熟时间更快。虽然NAH和P3潜伏期之间没有显着的关系，那些参与者与至少一个酗酒的父母有较长的P3潜伏期引起的困难的听觉任务。目标音产生的P3振幅和任何变量（年龄，性别，FH，NAH）之间没有显着的关系，结论：平均P3振幅和lavidity从这些使命印度青年的范围内，在文献中报道的其他种族的儿童和青少年的样本值。虽然P3 ERP测量的幅度已与FH的酒精中毒的研究中，主要是欧洲-美国人的个人，P3振幅产生的响应这些听觉任务并没有强大的区分使命印度儿童和青少年谁可能是在较高的风险，酒精中毒从那些假定为低风险。
Objective: Native Americans have some of the highest rates of alcohol abuse and dependence, yet potential biological risk factors associated with the problem drinking seen in many tribes remain relatively unknown. In this study, the amplitude of the P3 component of the event-related potential (ERP), a measure associated with risk for alcoholism in European-American youth, was investigated in Mission Indians. Method: The study participants were Mission Indian children and adolescents (N = 68, 37 male) between the ages of 7 and 13 years. ERPs were collected using two auditory "oddball" paradigms: an easy and a difficult discrimination task. P3 amplitude and latency were statistically evaluated as a function of age, gender, degree of Native American heritage (NAH) and family history (FH) of alcohol dependence. Results: P3 latency was found to vary as a function of age and gender, with girls demonstrating greater decreases in latency with age than boys, suggesting a faster maturation time. Whereas there were no significant relationships between NAH and P3 latency, those participants with at least one alcoholic parent had longer P3 latencies elicited by the difficult auditory task. No significant relationships were found between P3 amplitude generated to the target tones and any of the variables (age, gender, FH, NAH), Conclusions: Mean P3 amplitudes and latencies obtained from these Mission Indian youth were within the range of those values reported in the literature for samples of children and adolescents of other ethnicities. Although the amplitude of the P3 ERP measure has been associated with FH of alcoholism in studies of predominantly European-American individuals, P3 amplitudes generated in response to these auditory tasks did not robustly differentiate Mission Indian children and adolescents who may be at higher risk for alcoholism from those presumed to be at lower risk.