Respiratory-related evoked potential measures of respiratory sensory gating
Respiratory-related evoked potential measures of respiratory sensory gating
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DOI：
10.1152/japplphysiol.90722.2008
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发表时间：
2008-10-01
影响因子：
3.3
通讯作者：
Davenport, Paul W.
中科院分区：
文献类型：
--
作者：
Chan, Pei-Ying Sarah;Davenport, Paul W.
本研究的目的是使用成对刺激范例来展示神经呼吸门控系统。呼吸相关诱发电位（RREP）的N1峰代表呼吸感觉信息的早期知觉加工。这类似于触觉所示的N100峰，其中当刺激间隔500 ms时，来自体感诱发电位（SEP）的N100峰的第二峰幅度（S2）小于第一峰幅度（S1）。我们假设成对的吸气阻塞会导致S2 N1 RREP峰值振幅的降低，表明呼吸中枢神经门控。20名健康受试者（10名男性和10名女性; 25.8 ± 6.5岁）完成了配对吸气闭塞（RREP）试验。其中13名受试者还完成了配对的口腔空气抽吸[口腔诱发电位（MEP）试验]和配对的手部空气抽吸（SEP）试验。所有成对的演示被分开500毫秒。N1峰值振幅的RREP试验和N100峰值振幅的MEP和SEP试验的S1和S2和S2/S1的比率进行了测定。S1 RREP N1峰振幅显著大于S2，S2/S1比值为0.43。S1 MEP和SEP的N100峰值振幅均显著大于S2，N100比值分别为0.49和0.49。这些结果与呼吸传入输入的中枢神经门控一致。RREP门控反应类似于体感机械感受器门控。
The purpose of this study was to demonstrate a neural respiratory gating system using a paired stimuli paradigm. The N1 peak of the respiratory-related evoked potential (RREP) represents early perceptual processing of respiratory sensory information. This is similar to the N100 peak shown with tactile sensation, where the second peak amplitude (S2) of the N100 peak from the somatosensory evoked potential (SEP) was smaller than the first peak amplitude (S1) when the stimuli were presented 500 ms apart. We hypothesized that paired inspiratory occlusions would result in a reduced amplitude of the S2 N1 RREP peak amplitude, indicating respiratory central neural gating. Twenty healthy subjects (10 men and 10 women; 25.8 +/- 6.5 yr old) completed the paired inspiratory occlusion (RREP) trial. Thirteen of the subjects also completed the paired mouth air puffs [mouth-evoked potential (MEP) trial], and the paired hand air puffs (SEP) trial. All paired presentations were separated by 500 ms. The N1 peak amplitudes of the RREP trial and the N100 peak amplitudes of the MEP and SEP trials for S1 and S2 and the S2/S1 ratios were determined. The S1 RREP N1 peak amplitude was significantly greater than S2, and the S2/S1 ratio was 0.43. The S1 MEP and SEP N100 peak amplitudes were significantly greater than S2, and the N100 ratio was 0.49 and 0.49, respectively. These results are consistent with central neural gating of respiratory afferent input. The RREP gating response is similar to somatosensory mechanoreceptor gating.