Liberation and animation: strategies to minimize brain dysfunction in critically ill patients.
Liberation and animation: strategies to minimize brain dysfunction in critically ill patients.
复制标题
解放和活力：最大限度地减少危重患者脑功能障碍的策略。
DOI：
10.1055/s-0029-1246284
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发表时间：
2010
影响因子：
3.2
通讯作者：
Watson,PaulaL
中科院分区：
文献类型：
--
作者：
King,MatthewS;Render,MartaL;Ely,EugeneWesley;Watson,PaulaL
急性脑功能障碍，通常表现为谵妄，发生在高达80%的危重患者中。谵妄增加了住院费用，并影响短期结局，如机械通气持续时间、重症监护室（ICU）住院时间和住院时间。长期后果认知障碍和死亡风险增加可能是毁灭性的。为了充分认识和管理，必须实施一个成功的谵妄监测和评估策略。解放和动画策略可以减少谵妄的发生率和持续时间。Liberation旨在通过使用基于目标的镇静方案、自发觉醒试验和适当选择镇静剂以及从呼吸机和ICU中解放出来来减少镇静剂暴露的有害影响。动画是指早期动员，减少谵妄和改善神经认知结果。谵妄是一个严重的问题，具有重要的后果，可以使用我们在过去十年中学到的信息来预防或改善。
Acute brain dysfunction, usually manifested as delirium, occurs in up to 80% of critically ill patients. Delirium increases costs of hospitalizations and affects short-term outcomes such as duration of mechanical ventilation, intensive care unit (ICU) length of stay, and the hospital length of stay. Long-term consequences—cognitive impairment and increased risk of death—can be devastating. For adequate recognition and management it is imperative to implement a successful delirium monitoring and assessment strategy. A liberation and animation strategy can reduce both the incidence and the duration of delirium. Liberation aims to reduce the harmful effects of sedative exposure through use of target-based sedation protocols, spontaneous awakening trials, and proper choice of sedative as well as liberation from the ventilator and the ICU. Animation refers to early mobilization, which reduces delirium and improves neurocognitive outcomes. Delirium is a serious problem with important consequences and can be prevented or improved using the information that we have learned in the last decade.