Regulation of nitrogen metabolism in gram-positive bacteria
Regulation of nitrogen metabolism in gram-positive bacteria
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DOI：
10.1134/s0026893306050190
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发表时间：
2006-09-01
影响因子：
1.2
通讯作者：
Rodionov, D. A.
中科院分区：
文献类型：
--
作者：
Doroshchuk, N. A.;Gelfand, M. S.;Rodionov, D. A.
对负责革兰氏阳性菌氮同化的 TnrA 和 GlnR 调节子的新成员进行了搜索。分别针对 GlnR 和 TnrA 鉴定了具有共有序列 ATGTNAW-WWWWWWTNACAT 和 TGTNAWWWWWWWWWTNACA 的常见调节信号。描述了 TnrA/GlnR 调节子的结构，并在枯草芽孢杆菌、地衣芽孢杆菌、嗜地芽孢杆菌和伊海芽孢杆菌中发现了新的潜在成员； B. halodurans 中的 TnrA 调节子；乳酸乳球菌、植物乳杆菌、化脓性链球菌、肺炎链球菌、变形链球菌、无乳链球菌、粪肠球菌、单核细胞增生李斯特氏菌、金黄色葡萄球菌和表皮葡萄球菌中的 GlnR 调节子。
A search for new members of the TnrA and GlnR regulons, responsible for assimilation of nitrogen in Gram-positive bacteria, was performed. Common regulatory signals with consensus sequences ATGTNAW-WWWWWWTNACAT and TGTNAWWWWWWWTNACA were identified for GlnR and TnrA, respectively. The structure was described and new potential members were found in Bacillus subtilis, B. licheniformis, Geobacillus kaustophilus, and Oceanobacillus iheyensis for the TnrA/GlnR regulons; in B. halodurans for the TnrA regulon; and in Lactococcus lactis, Lactobacillus plantarum, Streptococcus pyogenes, S. pneumoniae, S. mutans, S. agalactiae, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, and St. epidermidis for the GlnR regulon.