The who, where, and when of IgE in allergic airway disease
The who, where, and when of IgE in allergic airway disease
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DOI：
10.1016/j.jaci.2011.10.029
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发表时间：
2012-03-01
影响因子：
14.2
通讯作者：
Lambrecht, Bart N.
中科院分区：
文献类型：
--
作者：
Dullaers, Melissa;De Bruyne, Ruth;Lambrecht, Bart N.
过敏性哮喘和变应性鼻炎/结膜炎的特点是吸入过敏原后，T(H)2主导的免疫反应与血清IgE水平升高相关。由于IgE在过敏性炎症的诱导和维持中起着关键作用，因此它是治疗干预的主要目标。然而，我们对IgE生物学的理解仍然是零碎的。本文将我们目前对过敏性气道疾病中IgE的了解结合起来，特别关注IgE分泌细胞的身份（“谁”），它们的位置（“在哪里”）以及它们被诱导的环境（“何时”）。我们进一步考虑所获得的见解的治疗意义。[J] .中华变态反应杂志，2012;29:635-45。
Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who''), their location ("where''), and the circumstances in which they are induced ("when''). We further consider the therapeutic implications of the insights gained. (J Allergy Clin Immunol 2012; 129: 635-45.)