Bifurcation analysis of a human ventricular myocyte model for biological pacemaker engineering
Bifurcation analysis of a human ventricular myocyte model for biological pacemaker engineering
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DOI：
10.1587/nolta.7.176
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Y. Ogawa;S. Doi
中科院分区：
文献类型：
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作者：
Y. Ogawa;S. Doi
生物起搏器是由正常静止的非起搏细胞产生的起搏细胞，有望成为电子起搏器的替代品。最近的生物起搏器工程研究表明，通过改变细胞膜上的离子电流可以增强心室肌细胞的起搏能力。我们使用一个精心设计的数学细胞模型进行分叉分析，以探讨一种有效的方法来创建生物起搏器从人类心室肌细胞。起搏器活动出现在IK1抑制期间。此外，我们表明，额外的增量ICaL，INaCa，或如果促进IK1减少条件下的起搏器活动的产生。
A biological pacemaker, which is a pacemaker cell created from normally quiescent non-pacemaking cells, is expected to be an alternative to electronic pacemakers. Recent studies on biological pacemaker engineering have revealed that a modification of ionic currents across the cell membrane elicits the pacemaking ability of a ventricular myocyte. We perform bifurcation analyses using an elaborate mathematical cell model to investigate an efficient way to create biological pacemakers from human ventricular myocytes. Pacemaker activity appears during the suppression of IK1. Furthermore, we show that an additional increment of ICaL, INaCa, or If facilitates the generation of pacemaker activity under IK1-reduced conditions.