Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.
Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.
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发表时间：
1993-11
期刊：
影响因子：
8
通讯作者：
L. Hwang;M. Siegelman;L. Davis;N. Oppenheimer-Marks;R. Baer
中科院分区：
文献类型：
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作者：
L. Hwang;M. Siegelman;L. Davis;N. Oppenheimer-Marks;R. Baer
TAL 1原癌基因编码碱性螺旋-环-螺旋（bHLH）蛋白，该蛋白与T细胞急性淋巴细胞白血病的发病机制有关。在造血谱系的红细胞、巨核细胞和肥大细胞中观察到TAL 1的正常表达。我们现在报告，TAL 1的RNA转录物和多肽产物都存在于体外培养的人脐静脉内皮细胞中。此外，原位杂交揭示了TAL 1在体内内皮细胞中表达的受限模式，包括脾的白色髓和滤泡内的血管。鉴于其作为转录因子的假定作用，TAL 1基因产物可在正常发育期间作为内皮细胞生长或分化的调节剂。
The TAL1 proto-oncogene encodes a basic helix-loop-helix (bHLH) protein that has been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. Normal expression of TAL1 is observed in erythrocytic, megakaryocytic and mastocytic cells of the hematopoietic lineage. We now report that both RNA transcripts and polypeptide products of TAL1 are present in human umbilical vein endothelial cells cultured in vitro. Moreover, in situ hybridization revealed a restricted pattern of TAL1 expression in endothelial cells in vivo, including vessels within the white pulp and follicles of the spleen. In view of its presumptive role as a transcriptional factor, the TAL1 gene product may serve during normal development as a regulator of endothelial cell growth or differentiation.