Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts
Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts
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DOI：
10.1158/1055-9965.epi-05-0059
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发表时间：
2005-09-01
影响因子：
3.8
通讯作者：
Fuchs, CS
中科院分区：
文献类型：
--
作者：
Schernhammer, ES;Hu, FB;Fuchs, CS
背景：糖尿病病史和高血糖负荷饮食都是胰腺癌的潜在危险因素。含糖软饮料是易吸收糖的主要来源，并与肥胖和糖尿病的风险增加有关。我们调查了高摄入含糖软饮料是否会增加患胰腺癌的风险。方法：我们在《护士健康研究》和《卫生专业人员随访研究》中考察了饮用含糖软饮料与胰腺癌发生的关系。在基线上没有癌症的88,794名女性和49,364名男性中，我们记录了长达20年的随访中的379例胰腺癌病例。结果：与基本上不喝含糖软饮料的参与者相比，每周饮用3种以上含糖软饮料的人患胰腺癌的多因素相对风险(RR)为1.1395%可信区间(95%CI)0.81-1.58；趋势P=0.471。摄入最多含糖软饮料的女性确实经历了显著的风险增加(RR，1.57；95%CI，1.02-2.41；趋势=0.05)，而在男性中，含糖软饮料摄入与胰腺癌之间没有关联。在女性中，含糖较高的软饮料的风险仅限于那些体重指数(>；25 kg/m(2)；RR，1.89；95%CI，0.96-3.72)或体力活动较少的人(RR，2.02；95%CI，1.06-3.85)。结论：尽管软饮料消费不会影响男性患胰腺癌的风险，但在存在潜在程度的胰岛素抵抗的女性中，饮用含糖软饮料可能会导致风险的轻微但显著增加。
Background: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk of pancreatic cancer.Methods: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.Results: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three sugar-sweetened soft drinks weekly expe-rienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95% confidence interval (95% CI), 0.81-1.58; P for trend = 0.471. Women in the highest category of sugarsweetened soft drink intake did experience a significant increase in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men. Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index (> 25 kg/m(2); RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% Cl, 1.06-3.85). In contrast, consumption of diet soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.Conclusion: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of insulin resistance.