Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films.
Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films.
复制标题
表层基质辅助激光解吸/电离质谱成像在载药聚（酯脲）薄膜中的应用。
DOI：
10.1016/j.aca.2023.341963
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发表时间：
2023
影响因子：
6.2
通讯作者：
Wesdemiotis,Chrys
中科院分区：
文献类型：
--
作者：
Williams-Pavlantos,Kayla;Brigham-Stinson,NatashaC;Becker,MatthewL;Wesdemiotis,Chrys
聚合物薄膜作为慢性病患者持续给药的一种方法，常用于透皮贴剂中。了解药物在这些膜中的分离和分布对于监测药物随时间的适当释放很重要。表面层基质辅助激光解吸/电离质谱仪成像(SL-MALDI-MSI)是一种独特的分析技术，它提供了存在于聚合物材料表面的化学成分的光学表示。无溶剂升华用于将基质应用到样品表面，因此只检测到与基质层直接接触的分子。在这里，这些方法被用来可视化药物载药聚合物膜中空气和基材界面上药物浓度的变化。
Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release over time. Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-MALDI-MSI) is a unique analytical technique that provides an optical representation of chemical compositions that exist at the surface of polymeric materials. Solvent-free sublimation is employed for application of matrix to the sample surface, so that only molecules in direct contact with the matrix layer are detected. Here, these methodologies are utilized to visualize variations in drug concentration at both the air and substrate interface in pharmaceutical-loaded polymer films.