Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report.
Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report.
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急性单核细胞白血病复发时谱系转变为急性淋巴细胞白血病：病例报告。
DOI：
10.1097/mph.0b013e318233219d
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Tamai H.
中科院分区：
文献类型：
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作者：
Inoue A;Kawakami C;Takitani K;Ikemoto T;Tamai H.
我们在此提出一例急性单核细胞白血病婴儿复发急性淋巴细胞白血病(ALL)的病例。经过急性髓系白血病定向化疗后，患者的病情完全缓解，但患者的前B-ALL复发。由于对急性髓系白血病再诱导治疗无反应，他改用全血型化疗，并实现了完全缓解。进行了无关的脐带血干细胞移植，但他再次患上了PRO-B。在接受了全型化疗后，他再次接受了人类白细胞抗原不匹配母亲的骨髓移植，8个多月来一直没有复发。
We herein present the case of an acute monoblastic leukemia infant who relapsed with acute lymphoblastic leukemia (ALL). Complete remission was achieved after an acute myeloblastic leukemia-directed chemotherapy, but the patient relapsed with pro-B ALL. As he did not respond to acute myeloblastic leukemia-type reinduction therapy, he was switched to ALL-type chemotherapy, and a complete remission was achieved. Unrelated cord blood stem cell transplantation was performed, but he relapsed with pro-B ALL again. After he received ALL-type chemotherapy, he underwent another bone marrow transplant from his human leukocyte antigen mismatch mother, and has been free from recurrence for over 8 months.