The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.
The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.
复制标题
哺乳动物靶标雷帕霉素、蛋白酪氨酸磷酸酶 1b 和二肽酶 4 信号通路在癌症和糖尿病中的参与：叙述性回顾。
DOI：
10.2174/1389557520666201113110406
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Shi Dayong
中科院分区：
文献类型：
--
作者：
Zhang Jiajia;Wu Ning;Shi Dayong
背景
BACKGROUND
The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes.
METHODOLOGY
We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer.
RESULTS
We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases.
CONCLUSION
There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.