Reversible cutaneous lymphoma occurring during methotrexate therapy
Reversible cutaneous lymphoma occurring during methotrexate therapy
复制标题
甲氨蝶呤治疗期间发生的可逆性皮肤淋巴瘤
DOI：
10.1046/j.1365-2133.1996.d01-946.x
复制
发表时间：
1996
影响因子：
10.3
通讯作者：
L. Lamant
中科院分区：
文献类型：
--
作者：
R. Viraben;P. Brousse;L. Lamant
总结1例58岁男性患者因非类风湿性外周关节炎接受甲氨蝶呤治疗，发生局限于皮肤的B细胞淋巴瘤，同时发生细胞溶解性肝炎和肺癌。甲氨蝶呤停药后两周，皮肤肿瘤和肝炎均自发消失，在12个月的随访期间没有复发。聚合酶链反应（PCR）显示免疫球蛋白基因重排，但原位杂交未能显示Epstein巴尔病毒（EBV）阳性的肿瘤细胞。
Summary A B‐cell lymphoma, restricted to the skin, developed in a 58‐year‐old man receiving methotrexate for non‐rheumatoid peripheral arthritis, with the simultaneous occurrence of a cytolytic hepatitis and carcinoma of the lung. Two weeks after methotrexate was stopped, both the skin tumour and the hepatitis disappeared spontaneously, with no recurrence during a 12‐month follow‐up period. Immunoglobulin gene rearrangement was shown by polymerase chain reaction (PCR) but in situ hybridization failed to reveal neoplastic cells positive for Epstein‐Barr virus (EBV).