The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
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DOI：
10.1016/j.brainres.2005.03.011
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发表时间：
2005-05-17
期刊：
影响因子：
2.9
通讯作者：
Bloom, SR
中科院分区：
文献类型：
--
作者：
Abbott, CR;Monteiro, M;Bloom, SR
迷走神经在胃肠道和大脑之间形成神经解剖学联系。许多胃肠激素，包括胆囊收缩素和胃饥饿素，需要一个完整的迷走神经-脑干-下丘脑通路来影响CNS摄食回路。我们已经表明，肽YY 3 -36（PYY 3 -36）和胰高血糖素样肽-1（GLP-1）的外周给药对啮齿动物的食物摄入和下丘脑弓状进食神经症的激活的作用在双侧延髓下迷走神经干全切断术或脑干-下丘脑通路横断后被消除。这些发现表明，迷走神经-脑干-下丘脑通路也可能在循环PYY 3 -36和GLP-1对食物摄入的影响中发挥作用。(c)2005 Elsevier B. V.保留所有权利。
The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have, shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurotics are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY3-36 and GLP-1 on food intake. (c) 2005 Elsevier B.V. All rights reserved.