Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons.
Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons.
复制标题
比较聚氯乙烯对巴氯芬诱导的超极化和从大鼠背外侧间隔神经元细胞内记录的突触介导的晚期超极化电位的拮抗作用。
DOI：
10.1016/0304-3940(88)90186-3
复制
发表时间：
1988
影响因子：
2.5
通讯作者：
Gallagher,JP
中科院分区：
文献类型：
--
作者：
Hasuo,H;Gallagher,JP
Phaclofen has recently been described as an antagonist to baclofen at both peripheral and central receptors. We have applied phaclofen in known concentrations to an isolated rat brain slice preparation containing the septal nuclei. Our data demonstrate that phaclofen antagonizes responses to exogenously applied baclofen in a competitive manner. On the other hand, phaclofen is not as effective in antagonizing competitively the synaptically mediated late hyperpolarizing response (LHP) recorded from the same or similar dorsolateral septal nucleus (DLSN) neurons from which baclofen responses were recorded. Our data support the usefulness of phaclofen as a competitive antagonist of baclofen, and suggest that when larger stimulus intensities are applied, the LHP in the dorsolateral septum of the rat may be mediated by a transmitter in addition to γ-aminobutyric acid (GABA).
