Recent advances in the synthesis of 2,3-fused quinazolinones
Recent advances in the synthesis of 2,3-fused quinazolinones
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DOI：
10.1039/d2ob00778a
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Gui-Fa Su
中科院分区：
文献类型：
--
作者：
Wang Wang;Pei-Sen Zou;Li Pang;Cheng-Xue Pan;Dong-Liang Mo;Gui-Fa Su
As one of the most important structural units in pharmaceuticals and medicinal chemistry, quinazolinone and its derivatives exhibit a wide range of biological and pharmacological activities, including anti-inflammatory, antitubercular, antiviral, and anticancer activities, etc. In particular, 2,3-fused quinazolinones have.attracted much attention because the rings fused to the 2,3-positions of quinazolinones improve their rigidity and planarity. Their synthetic strategies have made great advances in recent years. Therefore, this review focuses on novel strategies for the synthesis of 2,3-fused quinazolinone derivatives from 2017 to 2022, such as the difunctionalization of alkenes, the ring-opening of easily available small rings, dehydrogenative cross-coupling reactions, transition-metal catalyzed cyclizations, cycloadditions, and other cascade reactions.
