Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide
Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide
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DOI：
10.1039/c3cc40383a
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Ramamoorthy, Ayyalusamy
中科院分区：
文献类型：
--
作者：
Brender, Jeffrey R.;Krishnamoorthy, Janarthanan;Ramamoorthy, Ayyalusamy
人胰岛淀粉样多肽（hIAPP）的聚集与II型糖尿病中的β细胞死亡有关。分泌颗粒中存在的锌已被证明影响这种聚集。EXAFS，NMR和AFM实验的组合表明，锌的影响最有可能是由于稳定的prefibrillar聚集体的hIAPP。
The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.