Tangeretin, an extract from Citrus peels, blocks cellular entry of arenaviruses that cause viral hemorrhagic fever
Tangeretin, an extract from Citrus peels, blocks cellular entry of arenaviruses that cause viral hemorrhagic fever
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橘皮素是柑橘皮的提取物，可阻止引起病毒性出血热的沙粒病毒进入细胞
DOI：
10.1016/j.antiviral.2018.10.011
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发表时间：
2018-12-01
影响因子：
7.6
通讯作者：
Guo，Ying
中科院分区：
文献类型：
--
作者：
Tang，Ke;He，Shihua;Guo，Ying
沙粒病毒科由许多具有双义编码策略的包膜RNA病毒组成。已知包括拉沙病毒在内的八种沙粒病毒会在人类中引起严重和致命的病毒性出血热（VHF），但由沙粒病毒引起的疾病的疫苗和治疗方法非常有限。在这项研究中，我们筛选了由131种化合物组成的天然产物库，并确定了橘子素，一种广泛存在于柑橘果皮中的多甲氧基黄酮，作为拉沙病毒进入抑制剂，可阻断病毒融合。进一步的分析证明了柑橘素对其他七种引起VHF的沙粒病毒的有效性，这表明这种具有医疗使用历史的化合物可用于开发有效的治疗方法来治疗由拉沙病毒和相关病毒引起的感染和疾病。
The family Arenaviridae consists of numerous enveloped RNA viruses with ambisense coding strategies. Eight arenaviruses, including Lassa virus, are known to cause severe and fatal viral hemorrhagic fever (VHF) in humans, yet vaccines and treatments for disease caused by arenaviruses are very limited. In this study, we screened a natural product library consisting of 131 compounds and identified tangeretin, a polymethoxylated flavone widely present in citrus fruit peels, as a Lassa virus entry inhibitor that blocks viral fusion. Further analyses demonstrated the efficacy of tangeretin against seven other VHF-causing arenaviruses, suggesting that this compound, which has a history of medical usage, could be used to develop an effective therapeutic to treat infection and disease caused by Lassa virus and related viruses.