Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora
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DOI：
10.1126/science.1077336
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发表时间：
2002-11-15
期刊：
影响因子：
56.9
通讯作者：
Honjo, T
中科院分区：
文献类型：
--
作者：
Fagarasan, S;Muramatsu, M;Honjo, T
激活诱导的胞苷脱氨酶（AID）在免疫球蛋白基因的类转换重组（CSR）和体细胞超突变（SHM）中起着重要作用。我们在这里报告，缺乏艾滋病的结果在发展中的孤立淋巴滤泡（ILF）的增生与厌氧扩增100倍。在小肠中的口腔。减少细菌。经抗生素治疗的AID（-/-）小鼠的ora消除了ILF增生以及次级淋巴组织中观察到的生发中心扩大。由于不能自行转换为免疫球蛋白A不会导致类似的表型，因此这些结果表明ILF B细胞的SHM在调节肠道微生物菌群中起关键作用。
Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We report here that deficiency in AID results in the development of hyperplasia of isolated lymphoid follicles (ILFs) associated with a 100-fold expansion of anaerobic. ora in the small intestine. Reduction of bacterial. ora by antibiotic treatment of AID(-/-) mice abolished ILF hyperplasia as well as the germinal center enlargement seen in secondary lymphoid tissues. Because an inability to switch to immunoglobulin A on its own does not lead to a similar phenotype, these results suggest that SHM of ILF B cells plays a critical role in regulating intestinal microflora.