Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases.
Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases.
复制标题
粪便菌群移植百科全书：治疗85种疾病的有效性综述
DOI：
10.1097/cm9.0000000000002339
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发表时间：
2022-08-20
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
--
作者：
摘要粪便微生物群移植（FMT）通过重塑肠道微生物群，已被用作治疗生态失调相关疾病的核心疗法。FMT的方法学和技术不断进步，主要包括清洗菌群移植（WMT）、结肠经内镜肠内导管（泰特）输送菌群和从粪便中纯化厚壁菌门孢子。为了提高对FMT临床应用的理解，我们对2011年至2021年发表的FMT进行了系统的文献综述。在这里，我们从全球角度概述了FMT的临床获益、处理FMT的方法学、使用FMT的策略以及FMT的法规。最终分析共纳入782项研究。本综述概述了所有临床FMT用于85种特定疾病的有效性，分为8类，包括感染，肠道疾病，微生物-肠道-肝脏轴，微生物-肠道-脑轴，代谢疾病，肿瘤学，血液学疾病和其他疾病。尽管还需要进行更多的对照试验，但越来越多的报道表明，FMT在肠道或肠道外的生态失调相关疾病中具有广阔的前景。
Abstract Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified Firmicutes spores from fecal matter. To improve the understanding of the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits of FMT, the methodology of processing FMT, the strategy of using FMT, and the regulations on FMT from a global perspective. A total of 782 studies were included for the final analysis. The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories, including infections, gut diseases, microbiota–gut–liver axis, microbiota–gut–brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Although many further controlled trials will be needed, the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut.