Iatrogenic Hypercalcemia Due to Vitamin D3 Ointment (1,24(OH)2D3) Combined with Thiazide Diuretics in a Case of Psoriasis
Iatrogenic Hypercalcemia Due to Vitamin D3 Ointment (1,24(OH)2D3) Combined with Thiazide Diuretics in a Case of Psoriasis
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维生素D3软膏(1,24(OH)2D3)联合噻嗪类利尿剂致银屑病医源性高钙血症一例
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
S. Kondo
中科院分区：
文献类型：
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作者：
M. Kawaguchi;Y. Mitsuhashi;S. Kondo
他卡西醇是一种合成维生素D3类似物，开发用于局部治疗炎症性皮肤病，如银屑病。既往在外用他卡西醇治疗期间未报告高钙血症。我们经历了一个男性患者银屑病和高血压的条件下，他卡西醇软膏和噻嗪治疗，分别导致高钙尿症和高钙血症。开始外用维生素D3软膏（20 μg/g他卡西醇）10 g/天治疗皮肤病变后，血清钙水平和尿钙排泄量均逐渐增加。治疗第28天，他的血清钙水平达到3.55 mmol/l，尿钙排泄量也从0.008 g/天增加至0.475 g/天。终止他卡西醇治疗，7天后，血清钙水平已恢复至参考范围，无需任何特殊治疗。本病例是第一次报告的高钙血症引起的维生素D3软膏和噻嗪同时。
Tacalcitol is a synthetic vitamin D3 analogue developed for topical treatment of inflammatory skin diseases such as psoriasis. Hypercalcemia has not been previously reported during treatment with topical tacalcitol. We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia. After initiation of topical vitamin D3 ointment (20 μg/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually. On day 28 of the treatment, his serum calcium levels had reached 3.55 mmol/l, and his urinary calcium excretion had also increased from 0.008 g/day to 0.475 g/day. The tacalcitol treatment was terminated, seven days later, the serum calcium level had returned to the reference range without any specific treatment. The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.