Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers.
Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers.
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DOI：
10.3389/fendo.2016.00100
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发表时间：
2016
影响因子：
5.2
通讯作者：
Morrione A
中科院分区：
文献类型：
--
作者：
Tanimoto R;Lu KG;Xu SQ;Buraschi S;Belfiore A;Iozzo RV;Morrione A
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
