The role of the placenta in fetal programming - A review
The role of the placenta in fetal programming - A review
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DOI：
10.1053/plac.2002.0773
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发表时间：
2002-04-01
期刊：
影响因子：
3.8
通讯作者：
Godfrey, KM
中科院分区：
文献类型：
--
作者：
Godfrey, KM
胎儿起源假说提出，成人心血管和代谢疾病起源于发育可塑性和胎儿适应性，这些适应性是由于母体-胎盘的营养供应无法满足胎儿的需求而引起的。这一假设得到动物实验数据的支持，表明母体营养可以对后代产生长期影响，而不影响出生时的大小。现在有证据表明，孕妇的身体成分和怀孕期间营养摄入的平衡与后代心血管风险因素水平的提高有关。母体的身体组成和饮食被认为会影响胎儿的发育和编程，这是由于对胎儿的油基质可用性的直接影响和通过胎盘功能和结构的变化间接影响。胎盘生长和血管阻力的改变，胎盘中营养和激素代谢的改变，以及母亲、胎盘和胎儿之间营养转移和分配的变化，都对胎儿适应性产生重要影响，这些适应性被认为是编程的核心。未来改善胎盘功能的干预措施可能对后代终身健康有益。(C)2002年IFPA和Elsevier Science Ltd.
The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease originate through developmental plasticity and fetal adaptations arising from failure of the materno-placental supple of nutrients to match fetal requirements. The hypothesis is supported by experimental data in animals indicating that maternal nutrition can programme long term effects on the offspring without neccssarily affecting size at birth. There is now evidence linking body composition in pregnant women and the balance of nutrient intake during pregnancy with raised levels of cardiovascular risk factors in the offspring. Maternal body composition and diet are thought to affect fetal development and programming as I result of both direct effects oil substrate availability to the fetus and indirectly through changes in placental function and structure. Alterations in placental growth and vascular resistance, altered nutrient and hormone metabolism in the placenta, and changes in nutrient transfer and partitioning between mother, placenta and fetus all have important effects on the fetal adaptations thought to be central to programming. Future interventions to improve placental function are likely to have lifelong health benefits for the offspring. (C) 2002 IFPA and Elsevier Science Ltd.