Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via 19F NMR Barcodes
Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via 19F NMR Barcodes
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DOI：
10.1021/jacs.5b10934
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发表时间：
2015-12-16
影响因子：
15
通讯作者：
Schiller, Alexander
中科院分区：
文献类型：
--
作者：
Axthelm, Joerg;Goerls, Helmar;Schiller, Alexander
合成了衍生自4，4 '-、3，4'-和3，3 '-联吡啶的氟化硼酸附加的苄基联吡啶盐，并用于通过F-19 NMR光谱在生理条件下检测和区分含二醇的分析物。一个阵列的三个水溶性硼酸受体结合F-19核磁共振光谱辨别九个二醇含生物分析物-儿茶酚，多巴胺，果糖，葡萄糖，葡萄糖-1-磷酸，葡萄糖-6-磷酸，半乳糖，乳糖，蔗糖-在低mM浓度。特征NMR指纹被解释为二维条形码，而不需要多变量分析技术。
Fluorinated boronic acid-appended benzyl bipyridinium salts, derived from 4,4'-, 3,4'-, and 3,3'-bipyridines, were synthesized and used to detect and differentiate diol-containing analytes at physiological conditions via F-19 NMR spectroscopy. An array of three water-soluble boronic acid receptors in combination with F-19 NMR spectroscopy discriminates nine diol-containing bioanalytes-catechol, dopamine, fructose, glucose, glucose-1-phosphate, glucose-6-phosphate, galactose, lactose, and sucrose-at low mM concentrations. Characteristic NMR fingerprints are interpreted as two-dimensional barcodes without the need of multivariate analysis techniques.