ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
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ERIS 是一种内质网 IFN 刺激剂，通过二聚化激活先天免疫信号
DOI：
10.1073/pnas.0900850106
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发表时间：
2009-05-26
影响因子：
11.1
通讯作者：
Jiang, Zhengfan
中科院分区：
文献类型：
--
作者：
Sun, Wenxiang;Li, Yang;Jiang, Zhengfan
我们在此报告了一种蛋白质ERIS的鉴定和表征，ERIS是一种内质网（ER） IFN刺激剂，它是一种强I型IFN刺激剂，在响应非自胞质RNA和dsDNA中起关键作用。ERIS（也称为STING或MITA）只存在于内质网膜上。研究发现，内质网保留/检索序列RIR对于将蛋白质保留在内质网膜上并保持其完整性至关重要。ERIS在先天免疫挑战中是二聚体。coumermycin诱导的ERIS二聚化导致IFN强烈而快速的诱导，这表明ERIS二聚化对于自我激活和随后的下游信号传导至关重要。
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non-self-cytosolic RNA and dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The ER retention/retrieval sequence RIR was found to be critical to retain the protein on ER membrane and to maintain its integrity. ERIS was dimerized on innate immune challenges. Coumermycin-induced ERIS dimerization led to strong and fast IFN induction, suggesting that dimerization of ERIS was critical for self-activation and subsequent downstream signaling.