Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
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DOI：
10.1182/blood-2006-08-044008
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发表时间：
2007-03-01
期刊：
影响因子：
20.3
通讯作者：
Engels, Eric A.
中科院分区：
文献类型：
--
作者：
Landgren, Ola;Rapkin, Joshua S.;Engels, Eric A.
最近的证据表明，慢性淋巴细胞白血病（CLL）可能会发生以下的反应，感染剂。我们进行了一项基于人群的研究，包括1977年至1997年在丹麦诊断的4249例CLL患者和15690例频率匹配的对照，以量化各种气道感染后CLL的风险。通过数据链接，我们收集了医院住院/门诊出院的信息，列出了CLL前至少1年存在的感染。使用逻辑回归，我们计算了比值比（OR）和95%置信区间（CI）。肺炎个人史与CLL风险显著增加相关（OR = 1.4; 1.2-1.8）;风险限于CLL诊断前1 - 4.99年（OR = 1.6; 1.2-2.0）。既往有3次或3次以上肺炎事件的个体CLL风险显著升高2.5倍（1.1-5.6），且风险随肺炎发作次数增加而增加（P趋势<0.001）。其他9例泌尿道感染与CLL风险无显著相关性。肺炎可能是一个潜在的CLL触发器或它可能代表癌前免疫破坏前CLL。
Recent evidence suggests that chronic lymphocytic leukemia (CLL) might occur following a response to an infectious agent. We conducted a population-based study including 4249 CLL patients diagnosed in Denmark from 1977 to 1997 and 15 690 frequency-matched controls to quantify risk of CLL following various airway infections. Through data linkage we gathered information on hospital inpatient/outpatient discharges that listed infections present at least 1 year prior to CLL. Using logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (CIs). Personal history of pneumonia was associated with significantly increased CLL risk (OR = 1.4; 1.2-1.8); risk was restricted to 1 to 4.99 years prior to CLL diagnosis (OR = 1.6; 1.2-2.0). Individuals with 3 or more prior pneumonia events had a significant 2.5-fold (1.1-5.6) elevated CLL risk, and risk increased with the number of pneumonia episodes (P-trend < .001). None of 9 other respiratory-tract infections was significantly associated with CLL risk. Pneumonia might be a potential CLL trigger or it could represent premalignant immune disruption preceding CLL.