Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease
Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease
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DOI：
10.1186/s13195-019-0471-6
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发表时间：
2019-01-31
影响因子：
9
通讯作者：
Marshall, Gad A.
中科院分区：
文献类型：
--
作者：
Halawa, Omar A.;Gatchel, Jennifer R.;Marshall, Gad A.
研究背景工具性日常生活活动能力（IADL）的下降与轻度认知功能障碍（MCI）向阿尔茨海默病（AD）痴呆的进展相关，并与额叶和顶叶代谢减退、脑脊液淀粉样蛋白（1-42）降低和下颞叶皮质变薄有关。目的研究临床正常（CN）老年人、MCI和AD痴呆中IADL损伤与体内局部脑tau蛋白和皮质淀粉样蛋白沉积之间的关系。阿尔茨海默病神经成像倡议（ADNI）的9名AD痴呆参与者接受了用氟陶西匹（FTP）正电子发射断层扫描（PET）对局部tau沉积的评估。通过florbetapir PET评估皮质淀粉样蛋白负荷的聚集体。使用功能活动问卷（FAQ）评估IADL。使用与FAQ具有未校正相关性p <0.006（Bonferroni校正）的Tau区域，在单独的一般线性回归模型（向后消除）中评价FAQ（因变量）与局部脑tau沉积、淀粉样蛋白负荷和tau-淀粉样蛋白相互作用之间的横断面相关性。协变量包括年龄，美国国家成人阅读测试（AMNART）的智商（IQ），和雷伊听觉语言学习测试（RAVLT）总learning.ResultsUnadjusted FAQ和tau在内嗅皮层（EC）和下颞叶皮层（IT）之间的相关性生存Bonferroni校正。FAQ与tau蛋白-淀粉样蛋白相互作用相关，因此在淀粉样蛋白负荷较大的参与者中，IADL损伤较大与区域tau蛋白较大相关（EC tau x淀粉样蛋白：部分r（pr）=0.47，p
BackgroundA decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia and has been associated with frontal and parietal hypometabolism, lower cerebrospinal fluid amyloid (1-42), and inferior temporal cortical thinning. Identifying the underlying biomarkers of functional decline will allow for the early identification of individuals at risk of disease progression.ObjectiveTo investigate the association between IADL impairment and in vivo regional cerebral tau and cortical amyloid deposition across clinically normal (CN) elderly, MCI, and AD dementia.MethodsFifty-one CN elderly, 30 MCI, and 9AD dementia participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI) underwent assessment of regional tau deposition with flortaucipir (FTP) positron emission tomography (PET). An aggregate of cortical amyloid burden was assessed by florbetapir PET. IADL were assessed using the Functional Activities Questionnaire (FAQ). Tau regions with unadjusted correlations of p0.006 (Bonferroni correction) with FAQ were used to evaluate the cross-sectional association between FAQ (dependent variable) and regional cerebral tau deposition, amyloid burden, and tau-amyloid interaction in separate general linear regression models with backward elimination. Covariates included age, American National Adult Reading Test (AMNART) intelligence quotient (IQ), and Rey Auditory Verbal Learning Test (RAVLT) total learning.ResultsUnadjusted correlations between FAQ and tau in the entorhinal cortex (EC) and inferior temporal cortex (IT) survived Bonferroni correction. FAQ was associated with the tau-amyloid interaction, such that in participants with greater amyloid burden, greater IADL impairment was associated with greater regional tau (EC tau x amyloid: partial r (pr)=0.47, p