Long-term associations between early-life family functioning and preadolescent white matter microstructure.
Long-term associations between early-life family functioning and preadolescent white matter microstructure.
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DOI：
10.1017/s0033291722001404
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发表时间：
2023-07
影响因子：
6.9
通讯作者：
Kubzansky, Laura D.
中科院分区：
文献类型：
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作者：
Delaney, Scott W.;Xerxa, Yllza;Muetzel, Ryan L.;White, Tonya;Haneuse, Sebastien;Ressler, Kerry J.;Tiemeier, Henning;Kubzansky, Laura D.
儿童行为问题的原因仍然知之甚少。丰富的家庭环境和相应的大脑发育可能会降低其发病的风险，但研究白色物质神经发育途径解释家庭环境和行为之间的关联仍然有限。我们假设，更积极的产前和儿童中期家庭功能-一个家庭的问题解决和支持能力的措施-将与两个标志物的青春期前白色神经发育相关的减少行为问题：更高的全球各向异性分数（FA）和更低的全球平均扩散率（MD）。数据来自荷兰R世代研究中的2727个家庭。母亲在产前和儿童中期（平均年龄6.1岁）报告了家庭功能（McMaster家庭评估装置，范围1-4，分数越高表示功能越健康）。在青春期前（平均年龄10.1岁），研究收集了弥散加权扫描。我们通过平均27个白色物质束的指标计算标准化的全球MD和FA值，并拟合线性模型，调整可能的混杂因素，以检查全球和特定的结果。产前和儿童中期家庭功能评分中度相关，r = 0.38。然而，在完全校正的模型中，只有产前家庭功能-而不是儿童中期功能-与青春期前较高的总体FA和较低的总体MD相关：功能评分每增加一个单位，β总体FA = 0.11（95% CI 0.00，0.21）和β总体MD =-0.15（95% CI-0.28，-0.03）。敏感性和特定区域的分析支持这些全球调查结果。这些结果表明，高功能产前或围产期的家庭环境可能会赋予持久的白色物质的神经发育的好处到青春期前。
Causes of childhood behavior problems remain poorly understood. Enriched family environments and corresponding brain development may reduce the risk of their onset, but research investigating white matter neurodevelopmental pathways explaining associations between the family environment and behavior remains limited. We hypothesized that more positive prenatal and mid-childhood family functioning – a measure of a family's problem solving and supportive capacity – would be associated with two markers of preadolescent white matter neurodevelopment related to reduced behavior problems: higher global fractional anisotropy (FA) and lower global mean diffusivity (MD). Data are from 2727 families in the Generation R Study, the Netherlands. Mothers reported family functioning (McMaster Family Assessment Device, range 1–4, higher scores indicate healthier functioning) prenatally and in mid-childhood (mean age 6.1 years). In preadolescence (mean age 10.1), the study collected diffusion-weighted scans. We computed standardized global MD and FA values by averaging metrics from 27 white matter tracts, and we fit linear models adjusting for possible confounders to examine global and tract-specific outcomes. Prenatal and mid-childhood family functioning scores were moderately correlated, r = 0.38. However, only prenatal family functioning – and not mid-childhood functioning – was associated with higher global FA and lower global MD in preadolescence in fully adjusted models: βglobal FA = 0.11 (95% CI 0.00, 0.21) and βglobal MD = −0.15 (95% CI −0.28, −0.03) per one-unit increase in functioning score. Sensitivity and tract-specific analyses supported these global findings. These results suggest high-functioning prenatal or perinatal family environments may confer lasting white matter neurodevelopmental benefits into preadolescence.