Prenatal expression of growth hormone receptor/binding protein and insulin-like growth factor-I (IGF-I) in the enamel organ
Prenatal expression of growth hormone receptor/binding protein and insulin-like growth factor-I (IGF-I) in the enamel organ
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釉质器官中生长激素受体/结合蛋白和胰岛素样生长因子-I (IGF-I) 的产前表达
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Waters
中科院分区：
文献类型：
--
作者：
B. Joseph;N. Savage;W. Young;M. Waters
应用免疫组织化学方法研究生长激素受体结合蛋白（GHR/BP）和胰岛素样生长因子-I（IGF-I）在大鼠胚胎发育过程中的变化。连续切片的分析显示，GHR/BP和IGF-I在牙乳头和外胚层衍生的成釉器官的间充质内的芽和早期帽阶段的弥漫性染色。在过渡到帽状期之前，GHR/BP和IGF-I的免疫反应性在上皮芽中增加，并延伸到致密的牙间充质。在帽状期，牙上皮细胞显示出强烈的GHR/BP和IGF-I的表达，而牙间充质细胞显示出非常弱的染色。钟状期内釉上皮和外釉上皮GHR/BP和IGF-I均为阳性。分化期成釉细胞、成牙本质细胞和分泌期成釉细胞、成牙本质细胞继续表达GHR/BP和IGF-I。这些研究结果支持的前提下，生长激素和IGF-I可能发挥作用，在胚胎牙齿发育，通过调节上皮间质的相互作用，影响生长和细胞分化的事件。
Immunohistochemistry was used to study the ontogeny of GH receptor/binding protein (GHR/BP) and IGF-I from the 13-day-old embryo (E13) to the E19 rat fetus in the developing incisor and molar. Analysis of serial sections revealed diffuse staining of GHR/BP and IGF-I at the bud and early cap stages within both the mesenchyme of the dental papilla and the ectodermal-erived enamel organ. Just before transition to the cap stage, immunoreactivity of GHR/BP and IGF-I increased in the epithelial bud and extended to the condensed dental mesenchyme. At the cap stage, the dental epithelium showed an intense expression of GHR/BP and IGF-I, whereas the dental mesenchymal cells showed very weak staining. The inner enamel epithelium and the outer enamel epithelium were positive for both GHR/BP and IGF-I in the bell stage. Differentiating ameloblasts, odontoblasts and the secretory ameloblasts and odontoblasts continued to express GHR/BP and IGF-I in incisors. These findings support the premise that growth hormone and IGF-I may play a role in embryonic tooth development by regulating the epithelial-mesenchymal interactions that influence events in growth and cytodifferentiation.
生长调节素/胰岛素样生长因子和胎儿生长。
DOI：
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发表时间：
1987
期刊：
Journal of developmental physiology
影响因子：
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作者：
D'Ercole,AJ
通讯作者：
D'Ercole,AJ
胎儿生命期间血清生长调节素-C 循环形式的变化。
DOI：
10.1210/jcem-51-3-674
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
D'Ercole,AJ;Willson,DF;Underwood,LE
通讯作者：
Underwood,LE