Radiofrequency ablation of renal tumours: diagnostic accuracy of contrast-enhanced ultrasound for early detection of residual tumour
Radiofrequency ablation of renal tumours: diagnostic accuracy of contrast-enhanced ultrasound for early detection of residual tumour
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DOI：
10.1007/s00330-010-1742-6
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发表时间：
2010-08-01
影响因子：
5.9
通讯作者：
Correas, Jean-Michel
中科院分区：
文献类型：
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作者：
Hoeffel, Christine;Pousset, Maud;Correas, Jean-Michel
评价超声造影（CEUS）在肾肿瘤射频消融（RFA）后早期检测残留肿瘤的诊断准确性。转诊至我院接受肾肿瘤RFA的患者在治疗前、治疗后1天内和6周内前瞻性接受了CEUS和计算机断层扫描（CT）或磁共振成像（MRI）。由三名设盲的放射科医生评估残留肿瘤的识别。参考标准为RFA后至少1年进行的CT/MRI。研究了43例患者（中位年龄62岁;范围44-71.5岁）的66个肾肿瘤。CEUS的阅片者间一致性（kappa值）为0.84。残留病发生率为19%。24 h CEUS的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为64% [CI 39-84]、98% [CI 91-100]、82% [CI 52-95]和92% [CI 83-97]; 6周CEUS时为79% [CI 52-92]、100% [CI 94-100]、100% [CI 74-100]和95% [CI 87-100]; 24小时CT/MRI时为79% [CI 52-92]、95% [CI 86-98]、79% [CI 52-92]和95% [CI 86-98]; 6周CT/MRI检查的阳性率分别为100% [CI 72-100]、98% [CI 90-100]、91% [CI 62-98]和100% [CI 93-100]。
To evaluate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in the early detection of residual tumour after radiofrequency ablation (RFA) of renal tumours.Patients referred to our institution for RFA of renal tumours prospectively underwent CEUS and computed tomography (CT) or magnetic resonance imaging (MRI) before, within 1 day and 6 weeks after treatment. Identification of residual tumour was assessed by three blinded radiologists. Reference standard was CT/MRI performed at least 1 year after RFA.A total of 66 renal tumours in 43 patients (median age 62 years; range 44-71.5) were studied. Inter-reader agreement (kappa value) was 0.84 for CEUS. Prevalence of residual disease was 19%. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), respectively, were as follows: 64% [confidence interval (CI) 39-84], 98% [CI 91-100], 82% [CI 52-95] and 92% [CI 83-97] on 24-h CEUS; 79% [CI 52-92], 100% [CI 94-100], 100% [CI 74-100] and 95% [CI 87-100] on 6-week CEUS; 79% [CI 52-92], 95% [CI 86-98], 79% [CI 52-92] and 95% [CI 86-98] on 24-h CT/MRI; and 100% [CI 72-100], 98% [CI 90-100], 91% [CI 62-98] and 100% [CI 93-100] on 6-week CT/MRI.CEUS has high specificity for the early diagnosis of residual tumour after renal RFA.