Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination
Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination
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DOI：
10.1111/j.1440-1746.2006.04131.x
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发表时间：
2006-08-01
影响因子：
4.1
通讯作者：
Arakawa, Yasuyuki
中科院分区：
文献类型：
--
作者：
Mizuno, Shigeaki;Kato, Kimitoshi;Arakawa, Yasuyuki
背景和目的：据报道，在胃镜检查、结肠镜检查和双重对比钡灌肠检查中，腔内给药薄荷油（PO）是一种安全有效的解痉剂。本研究的目的是检查口服PO的疗效双对比钡餐检查（DCBM）没有其他antispasmodics.Methods：二百零五随机选择的主题（PO组）和215性别和年龄匹配的对照组。所有参与者都接受了DCBM。PO组在DCBM开始时口服PO和钡混悬液混合物。盲法评价X线片的痉挛和与钡填充的十二指肠袢重叠（评分为0-3，表示无至重度）。钡涂层的粘膜和整体诊断质量（评分0-3，表示不能接受优秀）的质量也evaluated.Results：有PO组和对照组之间的受试者接受度没有显着差异，在任何一组中没有不良反应。食管、胃下段和十二指肠球部痉挛评分PO组明显低于对照组（P < 0.001）。胃下段和十二指肠球部重叠评分PO组明显低于对照组（P < 0.05，P < 0.01）。PO组食管、胃下部和十二指肠球部的总体诊断质量评分显著高于对照组（P < 0.001）。结论：口服PO可减少食管、胃下部和十二指肠球部的痉挛，抑制钡剂流向十二指肠远端，在不使用其他解痉药的情况下提高诊断质量。口服PO是治疗DCBM的一种安全、简便、有效的解痉药。
Background and Aim: Intraluminally administered peppermint oil (PO) is reportedly a safe and useful antispasmodic for gastroscopy, colonoscopy and double-contrast barium enema. The aim of this study was to examine the efficacy of oral PO for double-contrast barium meal examination (DCBM) without other antispasmodics.Methods: Two hundred and five randomly chosen subjects (PO group) and 215 sex- and age-matched controls were enrolled. All participants underwent DCBM. The PO group was orally administered PO and a barium suspension mixture at the start of DCBM. Radiographs were blindly evaluated for spasm and overlapping with barium-filled duodenal loops (scored 0-3, indicating none to severe). The quality of barium coating of the mucosa and overall diagnostic quality (scored 0-3, indicating not acceptable to excellent) were also evaluated.Results: There was no significant difference in subject acceptance between PO group and controls, and no adverse effects in either group. Scores for spasm at the esophagus, lower stomach and duodenal bulb were significantly lower in the PO than in the control group (P < 0.001). Scores for overlapping at the lower stomach and duodenal bulb were significantly lower in the PO than in the control group (P < 0.05, P < 0.01, respectively). Scores for overall diagnostic quality at the esophagus, lower stomach and duodenal bulb were significantly higher in the PO than in the control group (P < 0.001).Conclusions: Oral PO reduces spasm of the esophagus, lower stomach and duodenal bulb, inhibits barium flow to the distal duodenum, and improves diagnostic quality without other antispasmodics. Oral PO is a safe, easy to use and effective antispasmodic for DCBM.