DNA methylation of viruses infecting a eukaryotic Chlorella-like green alga.
DNA methylation of viruses infecting a eukaryotic Chlorella-like green alga.
复制标题
感染真核小球藻样绿藻的病毒的 DNA 甲基化。
DOI：
10.1093/nar/13.10.3471
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发表时间：
1985
影响因子：
14.9
通讯作者：
Hattman,S
中科院分区：
文献类型：
--
作者：
VanEtten,JL;Schuster,AM;Girton,L;Burbank,DE;Swinton,D;Hattman,S
真核类小球藻绿藻、NC64A 菌株及其 11 种病毒的基因组 DNA 均含有显着水平的 5-甲基脱氧胞苷。此外，宿主DNA以及六种病毒DNA也含有N6-甲基脱氧腺苷。宿主中的至少一些甲基化碱基与病毒中的甲基化碱基存在不同的碱基序列，如对限制性内切核酸酶的不同易感性所示。这表明病毒编码的 DNA 甲基转移酶的序列特异性与宿主酶的序列特异性不同。
The genomic DNAs of the eukaryoticChlorella-like green alga, strain NC64A, and eleven of its viruses all contain significant levels of 5-methyldeoxycytidine. In addition, the host DNA as well as six of the viral DNAs also contain N6-methyldeoxyadenosine. At least some of the methylated bases in the host reside in different base sequences than the nethylated bases in the viruses as shown by differential susceptibility to restriction endonuclease enzymes. This suggests that the viruses encode for DNA methyltransferases with sequence specificities different from that of the host enzyme.