SYMPTOMATIC PATTERNS BIOLOGIC BEHAVIOR + PROGNOSIS IN CANCER OF LUNG - PRACTICAL APPLICATION OF BOOLEAN ALGEBRA + CLINICAL TAXONOMY
SYMPTOMATIC PATTERNS BIOLOGIC BEHAVIOR + PROGNOSIS IN CANCER OF LUNG - PRACTICAL APPLICATION OF BOOLEAN ALGEBRA + CLINICAL TAXONOMY
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DOI：
10.7326/0003-4819-61-1-27
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发表时间：
1964-01-01
影响因子：
39.2
通讯作者：
FEINSTEIN, AR
中科院分区：
文献类型：
--
作者：
FEINSTEIN, AR
目前的工作证明了传统的形态分析的必要性与分类的基础上的症状。一个先前构建的临床症状分类系统，利用布尔代数和符号逻辑的原则，已应用于肺癌。根据所表现的症状，将1954- 1958年间接受治疗的442例有组织学证据的肺癌患者分为6个临床亚组。结果证明了一种量化临床判断期望的方法，并有助于证实肺癌实体肿瘤的生物学预先定论假说。根据这一假说，如果肿瘤在解剖上可切除且生长缓慢，则最有可能治愈。数据显示，只有原发性症状发展缓慢的患者，以及在无症状时意外发现的患者，生存率最高。由于这些区别无法从标准的形态学评估中检测出来，因此数据表明，症状是人类肿瘤生物学行为的重要指标，特别是对于生长速度而言。
The present work demonstrates the necessity of conventional morphologic analyses with categorizations based on symptomatology. A previously-constructed system of classifying clinical symptoms, using principles of Boolean algebra and symbolic logic, has been applied to carcinoma of the lung. On the basis of the presenting symptoms, 442 patients with histologic evidence of lung cancer, treated during 1954-58, were divided into six clinical subgroups. The results demonstrate a method of quantifying the expectations of clinical judgment, and help confirm, in lung cancer, the biologic predeterminism hypothesis for solid neoplasms. According to this hypothesis, neoplasms are most likely to be curable if both anatomically excisable and slow-growing. As shown in the data, the best survival results occurred in patients with slow development of only primary symptoms, and in those discovered accidentally while asymptomatic. Since these distinctions could not have been detected from standard morphologic assessments, the data indicate that symptoms are important indices, particularly for rates of growth, of biologic behavior in human neoplasia.