Preserved performance in a hippocampal-dependent spatial task despite complete place cell remapping
Preserved performance in a hippocampal-dependent spatial task despite complete place cell remapping
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DOI：
10.1002/hipo.10047
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Strudwick, A
中科院分区：
文献类型：
--
作者：
Jeffery, KJ;Gilbert, A;Strudwick, A
海马定位细胞的空间定位放电被认为是海马导航功能的基础。因此，如果地图被破坏，使用特定的位置单元地图学习的空间任务的性能应该会恶化。为了验证这一预测，我们在一个黑盒子里训练大鼠完成一项依赖于营地的空间任务，并在一个白色盒子里测试它们。虽然从黑色到白色的变化引起了大多数位置细胞的重新映射，但导航性能基本上保持不变。此外，位置细胞的活动也与任务的特定方面无关，如音调起始，反应或目标位置。总之，这些结果意味着解决这个导航任务所需的空间信息是在海马体之外表示的，并表明位置细胞编码其他方面，如空间背景。(C)2003 Wiley-Liss，Inc.
The spatially localized firing of hippocampal place cells is thought to underlie the navigational function of the, hippocampus. Performance on a spatial task learned using a particular place cell map should therefore deteriorate if the map is disrupted. To test this prediction, we trained rats on a hippocampal-dependent spatial task in a black box and tested them in a white box. Although the change from black to white induced remapping of most place cells, navigational performance remained essentially intact. Furthermore, place cell activity was also unrelated to specific aspects of the task such as tone onset, response, or goal location. Together, these results imply that the spatial information needed to solve this navigation task is represented outside the hippocampus and suggest that the place cells encode some other aspect, such as the spatial context. (C) 2003 Wiley-Liss, Inc.