An Interference Localized Surface Plasmon Resonance Biosensor Based on the Photonic Structure of Au Nanoparticles and SiO2/Si Multilayers
An Interference Localized Surface Plasmon Resonance Biosensor Based on the Photonic Structure of Au Nanoparticles and SiO2/Si Multilayers
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DOI：
10.1021/nn800831a
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发表时间：
2009-02-01
期刊：
影响因子：
17.1
通讯作者：
Tamiya, Eiichi
中科院分区：
文献类型：
--
作者：
Hiep, Ha Minh;Yoshikawa, Hiroyuki;Tamiya, Eiichi
本文提出了一个原始的纳米结构设计的实验和模拟分析与等离子体金纳米粒子和光子薄膜多层的二氧化硅（500 nm厚）和硅基板上。我们的纳米结构基板表现出高灵敏度的各种折射率RI的解决方案和一个突出的功能化的金表面上的烷乙氧基化分子的能力，并展示了巨大的潜力，在开发基于微流体的生物传感器，用于监测生物素-亲和素相互作用的实时。
This paper presents the experimental and simulation analysis of an original nanostructure design constructed with plasmonic gold nanoparticles and photonic thin-film multilayers of silicon dioxide (500 nm in thickness) and silicon on a substrate. Our nanostructure substrate showed a high sensitivity for various refractive index RI solutions and a prominent capacity for functionalizing alkanethiol molecules on the gold surface and demonstrates great potential in the development of a microfluidic-based biosensor for monitoring biotin-avidin interactions in real-time.