Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex
Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex
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DOI：
10.1074/jbc.c111.255091
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发表时间：
2011-08-12
影响因子：
4.8
通讯作者：
Moran, Elizabeth
中科院分区：
文献类型：
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作者：
Flowers, Stephen;Beck, George R., Jr.;Moran, Elizabeth
哺乳动物DP，RB样，E2 F和MuvB样蛋白（DREAM）复合物，其关键组分包括p130和E2 F4，在生长停滞期间抑制细胞周期特异性基因中起着重要作用。哺乳动物的DREAM与果蝇和秀丽隐杆线虫的复合体很保守，它们抑制关键的发育基因，但哺乳动物的复合体被认为只存在于静止细胞中，与发育无关。然而，这里的新发现确定了增殖前体中被DREAM抑制的组织特异性启动子，揭示了生长停滞控制和终末分化之间的新联系。从机制上讲，DREAM对组织特异性启动子的占据依赖于SWI/SNF染色质重塑复合物的阻遏形式的完整性。
The mammalian DP, RB-like, E2F, and MuvB-like proteins (DREAM) complex, whose key components include p130 and E2F4, plays a fundamental role in repression of cell cycle-specific genes during growth arrest. Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been thought to exist only in quiescent cells and not to be linked with development. However, new findings here identify tissue-specific promoters repressed by DREAM in proliferating precursors, revealing a new connection between control of growth arrest and terminal differentiation. Mechanistically, tissue-specific promoter occupation by DREAM is dependent on the integrity of a repressor form of the SWI/SNF chromatin-remodeling complex.