Possibility of thermosensitive magnetoliposomes as a new agent for electromagnetic induced hyperthermia.
Possibility of thermosensitive magnetoliposomes as a new agent for electromagnetic induced hyperthermia.
复制标题
热敏磁脂质体作为电磁诱导热疗新剂的可能性。
DOI：
10.1248/bpb.18.1802
复制
发表时间：
1995
影响因子：
2
通讯作者：
I. Horikoshi
中科院分区：
文献类型：
--
作者：
Y. Masuko;K. Tazawa;E. Viroonchatapan;S. Takemori;T. Shimizu;M. Fujimaki;H. Nagae;H. Sato;I. Horikoshi
本研究探讨了葡聚糖磁铁矿（DM）掺入的热敏脂质体，即热敏磁性脂质体（TM），作为一种新的热疗剂的可能性。在体外和体内条件下，通过频率为500 kHz的电磁感应加热，TM悬浮液和注射有TM悬浮液的癌症肿瘤的温度有效地升高至42 ℃。因此，证明了TM用于选择性高温的可能性。在不同浓度的TM下获得的温度升高表明，约15 mg Fe/cm 3肿瘤体积足以作为有效选择性热疗的治疗剂量的TM。
This study examined a possibility of dextran magnetite (DM)-incorporated thermosensitive liposomes, namely thermosensitive magnetoliposomes (TMs), as a new hyperthermic agent. The temperatures of TM suspensions and cancer tumors injected with TM suspensions were efficiently elevated up to 42 degrees C by electromagnetic induced heating at a frequency of 500 kHz under both in vitro and in vivo conditions. Thus, a possibility of TMs for selective hyperthermia was demonstrated. The temperature rises obtained at various concentrations of TMs suggest that approximately 15 mg Fe/cm3 tumor volume is adequate as a therapeutic dose of TMs for efficient selective hyperthermia.