AMYGDALA PATHOLOGY IN PARKINSONS-DISEASE
AMYGDALA PATHOLOGY IN PARKINSONS-DISEASE
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DOI：
10.1007/bf00296485
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发表时间：
1994-12-01
影响因子：
12.7
通讯作者：
JELLINGER, K
中科院分区：
文献类型：
--
作者：
BRAAK, H;BRAAK, E;JELLINGER, K
在帕金森病（PD）的过程中，杏仁核经历了严重的病理改变。路易小体和路易神经突在整个核复合体中以特定的方式分布。病变模式在个体间只有很小的差异。最显著的变化发生在副皮质核和中央核。皮质核、副基核和颗粒核的改变不太严重，而基核和侧核以及嵌入的细胞团一般不受影响。杏仁核接收范围广泛的事件，允许外感受信息与内感受数据的整合。它主要投射到同皮层（尤其是前额皮质）、边缘系统（海马和内嗅区）以及调节内分泌和自主神经功能的中枢。PD的特殊病变模式破坏了部分核灰质及其连接，因此可能导致行为改变和自主神经功能障碍的发展。
The amygdala undergoes severe pathological changes during the course of Parkinson's disease (PD). Lewy bodies and Lewy neurites are distributed in a specific manner throughout the nuclear complex. The lesional pattern displays only minor interindividual variation. The most prominent changes occur in the accessory cortical and central nuclei. The cortical, accessory basal and granular nuclei show less severe alterations, while the basal and lateral nuclei, as well as the intercalated cell masses, generally remain uninvolved. The amygdala receives a broad range of afferents, allowing integration of exteroceptive information with interoceptive data. It generates major projections to the isocortex (the prefrontal cortex in particular), limbic system (hippocampus and entorhinal region) and centers regulating endocrine and autonomic functions. The specific lesional pattern seen in PD destroys part of the nuclear gray matter and its connections and, thus, may likely contribute to the development of behavioral changes and autonomic dysfunctions.