Comparative gross anatomy of epicardiac ganglionated nerve plexi on the human and sheep cardiac ventricles.
Comparative gross anatomy of epicardiac ganglionated nerve plexi on the human and sheep cardiac ventricles.
复制标题
人和羊心室心外膜神经丛的比较大体解剖学。
DOI：
10.1002/ar.25085
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Pauza,DainiusH
中科院分区：
文献类型：
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作者：
Saburkina,Inga;Pauziene,Neringa;Solomon,OnItai;Rysevaite-Kyguoliene,Kristina;Pauza,DainiusH
本研究旨在检查人类和绵羊心脏中心外膜室神经节丛的分布和定量参数，强调该神经丛在人类和大型模型中的差异。研究人员采用乙酰胆碱酯酶组织化学方法对 5 颗人类新生儿的非切片压力扩张全心和 10 颗新生德国黑脸羔羊的心脏进行了研究，以对心外膜神经结构进行染色，并随后进行立体显微镜检查。在人类中，心室神经由四个心外膜神经亚丛分布，即左、右冠状动脉以及左、中背神经。绵羊的心室神经由五个心外膜神经亚丛分布，即左、右冠状动脉、左、中背神经和右腹神经。人类的心室外膜涉及多达 129 个神经节，绵羊的心室外膜涉及多达 198 个神经节。人类中数量最多的心室神经节细胞位于腹侧、动脉圆锥前面，而在绵羊心室中，数量最多的神经元分布在左心室的背壁上。这项对人类和绵羊心室形态模式的比较研究表明，绵羊心脏在神经解剖学上与人类心脏不同，在使用绵羊模型进行心脏生理学实验时必须考虑到这一点。
This study aimed to examine the distribution and quantitative parameters of the epicardiac ventricular neural ganglionated plexus in the hearts of humans and sheep, highlighting the differences of this plexus in humans and large models. Five non‐sectioned pressure distended whole hearts of the human newborns and 10 hearts of newborn German black‐faced lambs were investigated applying a histochemical method for acetylcholinesterase to stain epicardiac neural structures with their subsequent stereomicroscopic examination. In humans, the ventricular nerves are spread by four epicardiac nerve subplexuses, that is, the left and right coronary as well as the left and middle dorsal. In sheep, the ventricular nerves are spread by five epicardiac nerve subplexuses, that is, the left and right coronary, the left and middle dorsal and the right ventral ones. The ventricular epicardium involved up to 129 ganglia in humans and up to 198—in sheep. The largest number of the ventricular ganglionic cells in humans were located on the ventral side, in front of the conus arteriosus, while on sheep ventricles, the most numerous neurons distributed on the dorsal wall of the left ventricle. This comparative study of the morphological patterns of the human and sheep ventricles demonstrates that the sheep heart is neuroanatomically distinct from the human one and this must be taking into consideration using the sheep model for the heart physiology experiments.