Selective palladium-catalyzed arylation of ammonia: Synthesis of anilines as well as symmetrical and unsymmetrical Di- and triarylamines
Selective palladium-catalyzed arylation of ammonia: Synthesis of anilines as well as symmetrical and unsymmetrical Di- and triarylamines
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DOI：
10.1021/ja074681a
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发表时间：
2007-08-29
影响因子：
15
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Surry, David S.;Buchwald, Stephen L.
结果表明，通过选择合适的钯/配体体系、温度、浓度和试剂的化学计量比，氨可以选择性地芳基化得到苯胺、对称的二芳胺或三芳胺。此外，可以将不同的芳基卤化物顺序地添加到反应混合物中，从而允许以一锅法从芳基卤化物和氨合成不对称的二芳胺和三芳胺
It is shown that by selection of an appropriate palladium/ligand system, temperature, concentration, and stoichiometry of reagents, ammonia may be selectively arylated to give either anilines, symmetrical di-, or triarylamines. Furthermore different aryl halides may be added sequentially to the reaction mixture, allowing the synthesis of unsymmetrical di- and triarylamines from aryl halides and ammonia in a one-pot protocol