Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening.
Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening.
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DOI：
10.1039/c3cc49771b
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发表时间：
2014-02
影响因子：
4.9
通讯作者：
Qin Wu;Dan Gao;Juntong Wei;Feng Jin;W. Xie;Yuyang Jiang;Hongxia Liu
中科院分区：
文献类型：
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作者：
Qin Wu;Dan Gao;Juntong Wei;Feng Jin;W. Xie;Yuyang Jiang;Hongxia Liu
A novel multi-layer microfluidic device was developed for characterization of drug metabolism in human liver microsomes (HLMs) and their cytotoxicity on cells. The results demonstrated that this platform is robust for low levels of compounds and shows potential for high-throughput drug screening in drug development.
