INCREASED PLASMA-LIPID PEROXIDATION IN RIBOFLAVIN-DEFICIENT, MALARIA-INFECTED CHILDREN
INCREASED PLASMA-LIPID PEROXIDATION IN RIBOFLAVIN-DEFICIENT, MALARIA-INFECTED CHILDREN
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DOI：
10.1093/ajcn/51.5.859
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发表时间：
1990-05-01
影响因子：
7.1
通讯作者：
BOSE, TK
中科院分区：
文献类型：
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作者：
DAS, BS;THURNHAM, DI;BOSE, TK
采用硫代巴比妥酸 (TBA) 法对 75 名患有恶性疟原虫疟疾的儿童进行血浆脂质过氧化物测定，以丙二醛 (MDA) 形式进行测定。通过测量红细胞谷胱甘肽还原酶激活系数（EGRAC）来评估他们的核黄素状态，值> 1.40被认为表明生化缺乏。患者血浆 MDA 高于对照组 (p < 0.001)；浓度为3.65.+/-。 0.70 和 1.77.+-。分别为0.45.mu.mol/L(.hivin.x.+-.SD)。核黄素缺乏组的血浆MDA值（3.98±0.70μmol/L）高于非缺乏组（3.30±0.68μmol/L，p<0.001）。患者血浆 MDA 浓度与 EGRAC 相关（r = 0.46，p < 0.01）。有人提出，核黄素缺乏会限制还原型谷胱甘肽的再生，使寄生的红细胞更容易受到破坏性脂质过氧化作用的影响，并增加血浆脂质氢过氧化物。
Plasma lipid peroxides were measured as malonyldialdehyde (MDA) by the thiobarbituric acid (TBA) method in 75 children suffering from Plasmodium falciparum malaria. Their riboflavin status was assessed by measuring erythrocyte glutathione reductase activation coefficients (EGRACs), and values > 1.40 were regarded as indicating biochemical deficiency. Plasma MDA was higher (p < 0.001) in patients than in control subjects; the concentrations were 3.65 .+-. 0.70 and 1.77 .+-. 0.45 .mu.mol/L (.hivin.x .+-. SD), respectively. The riboflavin-deficient group had higher plasma MDA values (3.98 .+-. 0.70 .mu.mol/L) than did the nondeficient group (3.30 .+-. 0.68 .mu.mol/L, p < 0.001). Plasma MDA concentrations correlated with EGRACs (r = 0.46, p < 0.01) in the patients. It is proposed that riboflavin deficiency restricts regeneration of reduced glutathione making the parasitized erythrocytes more vulnerable to destructive lipid peroxidation and increasing plasma lipid hydroperoxides.